Glucosamine and chondroitin have been heavily studied by many researchers. Trial after trial, study after study has shown effectiveness of these two supplements. Now the big guns of the National Institute of Health wanted to see what they could find out - are you ready?

They found glucosamine and chondroitin to be significantly effective in providing joint pain relief. Surprised? I'm not but I'm glad that it confirms the point home to those who question them. Having seen numerous patients on these two supplements, I have become a firm believer in the potent effects of glucosamine sulfate and chondroitin sulfate.

WASHINGTON, D.C., November 13, 2005 ­­ — The Council for Responsible Nutrition (CRN) said today osteoarthritis patients should welcome the results of a new clinical trial sponsored by the National Institutes of Health (NIH) that showed that the combined use of two dietary supplements—glucosamine and chondroitin—provided significant pain relief for sufferers of the joint disease that afflicts tens of millions of Americans.

The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) adds to a growing body of scientific evidence showing that the two supplements can safely alleviate pain from osteoarthritis, a chronic condition known as the “wear-and-tear” kind of arthritis that afflicts 21 million Americans each year. Sixty-six million Americans—nearly one in 3 adults—have various forms of arthritis, the leading cause of disability among Americans over age 15, according to the Arthritis Foundation.

The six-month GAIT study involved 1,500 osteoarthritis patients who were given a placebo or daily doses of 1,500/mg of glucosamine hydrochloride and/or 1,200 mg of chondroitin sulfate or 200 mg of the common prescription pain medication celecoxib. GAIT found that a combination of the two supplements “is effective in treating moderate to severe knee pain due to osteoarthritis.”

The new findings are consistent with the vast majority of more than 50 published clinical trials that have demonstrated the safety and benefit of the two supplements, said Andrew Shao, Ph.D., CRN’s vice president of scientific and regulatory affairs. “This gold-standard NIH-sponsored study adds to the strong body of human clinical trials that supports the use of glucosamine and chondroitin for significant and long-lasting relief of joint pain and improvements in mobility,” Dr. Shao said. “The body of science demonstrates that these supplements are both safe and beneficial for joint health.”

In other research, preliminary results from a 24-week clinical trial in Europe—Glucosamine Unum in Die Efficacy (GUIDE) Trial—found that glucosamine sulfate was more effective in relieving osteoarthritis pain than the pain medicine acetaminophen.

Results of both the GAIT and GUIDE studies are being presented this week at the annual scientific meeting of the American College of Rheumatology (ACR) in San Diego and abstracts are posted on ACR’s website

Commenting from the ACR meeting, Dr. Shao said research also suggests that glucosamine and chondroitin may similarly help others at risk for osteoarthritis or those who are experiencing joint discomfort, including athletes involved in high-impact sports such as basketball or running.

“We believe that the results from this well-executed NIH-sponsored study not only indicate that more research is needed to determine the full potential of glucosamine and chondroitin, but also reconfirm that these supplements can help the growing number of Americans with joint problems reduce the pain of osteoarthritis,” he said.

An effective supplement that is designed to support joint health is ArthroGenX. ArthroGenX contains high amounts of both glucosamine and chondroitin along with herbal anti-inflammatory support.

For other studies on glucosamine, visit the blog entry on glucosamine vs. ibuprofen.