Seeking Health HomocysteX

HomocysteX by Seeking Health supplies bioactive forms of four essential B-vitamins together without TMG (trimethylglycine) to synergistically support methylation processes and normal homocysteine metabolism. This formula is exceptional for those with defective MTHFR genes. Taking just 5-MTHF is not sufficient for those with MTHFR mutations which is why Dr Ben provides these other ingredients to help lower homocysteine and support the methylation cycle.

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$24.00

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Why choose HomocysteX by Seeking Health?

The body’s methylation process is vital for formation of essential cell components such as proteins, nucleicacids found in DNA and RNA, and phospholipids that form nerve cell membranes. By transferring methyl groups (three hydrogen atoms bonded to a carbon atom, known as CH3) from one molecule to another, methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite. Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body. To nutritionally support optimal methylation capacity, this product supplies folate, vitamin B12, and B6.

Key Ingredients, Benefits and Actions of Homocystex by Seeking Health

Provides vitamin B12 as methylcobalamin: Vitamin B12 is crucial to the formation of healthy red blood cells, energy production, nervous system support, cognitive function, and homocysteine regulation. Although cyanocobalamin is the most commonly used form of vitamin B12 in dietary supplements, it must be converted by enzymes into an active coenzyme form to be useful. Nutritional inadequacies, enzyme defects, and tissue abnormalities can reduce the body’s ability to synthesize the active forms of B12. In contrast, vitamin B12 as methylcobalamin is a “body-ready” form with metabolic benefits that may not be provided by other forms of vitamin B12. It appears that methylcobalamin may be particularly useful for individuals with impaired methylation capacity, including those with elevated homocysteine or neurological impairments.

Supplies an active form of folate: This B-vitamin is crucial for generating red blood cells, regulating homocysteine metabolism, assisting DNA repair, and supporting neurological processes. Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF), an active form of folate, is included in this product to help ensure more immediate effects on metabolism compared to folic acid, the form of folate commonly used in fortified foods and supplements.

Contains the active, coenzyme form of B6: Vitamin B6 is necessary for many aspects of health including protein and amino acid metabolism, red blood cell formation, normal brain function, and synthesis of antibodies important for optimal immune responses. Pyridoxal 5’-phosphate (P-5-P) is a body-ready form with metabolic benefits that may not be provided by other forms of vitamin B6. Although pyridoxine hydrochloride is the most commonly used form of vitamin B6 in dietary supplements, it must be converted to the active coenzyme form, P-5-P, to be useful. Nutritional inadequacies, certain medications, compromised liver function, and enzyme defects can reduce the body’s ability to convert B6 forms such as pyridoxine hydrochloride to P-5-P. In contrast, vitamin B6 as P-5-P is already fully “active” and readily usable, as it does not require further transformation in the body.

What makes HomocysteX superior to other B-Vitamin supplements on the market? HomocysteX by Seeking Health supplies bioactive forms of four essential B-vitamins to synergistically support methylation processes and normal homocysteine metabolism. This formula is exceptional for those with defective MTHFR genes. Taking just 5-MTHF is not sufficient for those with MTHFR mutations which is why Dr Ben provides these other ingredients to help lower homocysteine and support the methylation cycle.

Individuals most at increased risk for vitamin B12, folate, and vitamin B6 deficiencies are the elderly, vegetarians, and individuals with ulcers, Crohn’s disease, and bacterial overgrowth. This dietary supplement may be especially beneficial for persons with impaired gastrointestinal absorptive function due to aging, illness, or surgery.

Brand: Seeking Health
SKU: SKH026
Delivery type: Vegetarian Capsule
MPN: 023-05-002-24
Made In: Canada
Serving size: 1
Servings per container: 60 Vegetarian capsules

Supplement Facts:
Vitamin B6 (from 41 mg pyridoxal 5’-phosphate) 25mg 1250%
Folate (as Metafolin L-5-methyltetrahydrofolate) 800 mcg 200%
Vitamin B12 (as methylcobalamin 1000 mcg16,667%
 * = Daily Value Based on a standard 2,000 calorie daily intake
** = Daily Value Not Established

Other Ingredients
Vegetarian capsule (hydroxypropyl methylcellulose, water), cellulose, L-leucine, and silicon dioxide.

Suggested Use
1 capsule daily with food or as directed by your physician. May be combined with L-5-MTHF 1000 by Seeking Health should additional methylated folate be required.

Warnings
Keep Out Of Reach Of Children

Does not contain: Casein, Corn, Dairy, Egg, Fish, Peanuts, Shellfish, Soy, Tree Nuts, Wheat

Customer Reviews

  1. One month on Homocystex changed my health dramatically. Review by Vicks

    I was taking several things my doctor recommended to help my MTHFR double mutation. After 5 months there was very little change. I took the Homocystex and after 1 month my health changed dramatically. I recommended it to my sister who has this same mutation and she had the same results. Thanks so much for a product that is helping so many.

    Order # 166406 (Posted on 10/17/12)

  2. Great Review by KTR

    Great product for women with MTHFR

    Order # 170419 (Posted on 10/17/12)


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Questions on Seeking Health HomocysteX

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  • Homocystex at 2/27/12 9:56 PM
    • I just noticed this product is the same name as what I ordered before, but the one I have contains the added ingredients of B-2 and TMG. Do you have two separate products? Homocystex and Homocystex Plus?
      I was curious, because my label just shows Homocystex. Thanks.
    • Hi there - We recently added HomocysteX which does not have B2 or TMG. We named the product which has TMG and B2, HomocysteX Plus. We found there are people who do not tolerate TMG well which is why we brought in HomocysteX. If you purchased this in error, let us know and we will cover your shipping costs. We tried making it clear on the site but we realize that some people who purchased HomocysteX in the past meant to order HomocysteX Plus. Best Dr Ben
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  • Methyl B12 at 5/22/12 4:51 AM
    • I was under the impression that methyl B12 did not absorb well taken internally, so how can the MB12 in your product possibly benefit me?
    • Hello - 

      Most individuals do well with methylcobalamin when taken orally - especially when taken on an empty stomach or away from meals/food by 20 minutes.

      People with pernicious anemia should take sublingual methylcobalamin and/or injectable B12.

      If you have low stomach acid or pernicious anemia, then taking HomocysteX is not your best option.

      The best option for you in this case would be Sublingual Active B12 with Metafolin.

      In health,

      Dr Ben

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  • Homocystex and prescription folgard at 5/24/12 12:41 PM
    • Hi Dr. Ben,
      I am looking into purchasing this. Just found out about the gene after recurrent miscarriages. No one seems to know much about this so I am doing the research on my own. I am Homozygous A1298C would it be harmful to take the homocystex along with the prescription folgard my gyno gave me? I am preparing for IVF and want to make sure I am healthy and everything goes well to keep this baby. Also, anything else you reccommend taking? I know my Vitamin D levels always come back dangerously low. I want to know all around what should I be taking/doing as I prepare for IVF, and to just live life in general. I was thinking I should also start taking a baby aspirin daily. Please help!
    • Hello - 

      Please read this article on prenatal supplementation and MTHFR.

      Low vitamin D3 can be replenished by taking a liquid vitamin D3 at 2,000 IU per drop. Consider taking 5 drops daily until your levels get where they need to be. Then once pregnant, reduce to 3 drops daily - and also take this amount while breast feeding.

      Low iron is also known to be a cause in low vitamin D3. Consider having your doctors check your 'serum ferritin' levels. If they are low, then supplementing with a quality iron supplement that is easy on your stomach is needed. Consider taking 1 a day before meals.

      In the article I mention above, I also recommend:

      - Active CoQH: 1 capsule daily which contains 50 mg. Take daily with breakfast or lunch- Probiota 12: 1 capsule daily after dinner 

      In terms of taking HomocysteX and Folgard - that may be excessive. However, HomocysteX has the more active forms of folate and B12 and b6 compared to Folgard.

      Folgard does not contain the more active forms of folate or the good forms of vitamin B12. 

      Folgard ingredients are here

      Taking a capsule of HomocysteX in the AM upon rising and your Folgard before lunch may be a good combination. Please do run this by your doctor and see what they recommend or if they are ok with this thought process.

      Baby aspirin may be a good idea as there are many clotting disorders that are not commonly screened for - and some clotting disorders are passed on by the father's genetics which do affect the health of the developing baby.

      In health,

      Dr Ben

       

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  • Fem MTHFR double copy stopped warfarin against Drs order 7 mos ago now short of breath at 6/21/12 7:06 AM
    • Im 45 no kids diag w MTHFR after couldnt breathe rushed to ER foudn i had 6 Pulm embolsims and double pneumonia . IM disabled w perm spine defomrity from failed scolisosi surgery resulted in Flatback deformity intractable pain i am bent forward cant stnad erect loss of relfexes in entremiteis from spine bilateral stenosis and left leg goes dead , cannot stnd erect and cant sleep in a bed for 3 yrs i sleep in a chair , took 8 mos for clots to go away HEMO ONNCO Dr did genetic test foudn i had MTHFR and put me warfarin rest of life in 09 began immed losign my long thick hair badly

      I dont eat veges told i coulndt have greens, have NO appetite have eaten lo carb atkins bars for 2 yrs and water and cofee thats it, I still gain weight amd housebound he did CBC checked tyroid said fine but gain weight>
      never had kids cant w my spine and live alone mobility is terrible. Would
      HomocysteX 60 help me stay in INR PROTIME therapeutic range w out blood tests and thinners? I was on 800000 units of vit d a day and folate wich i had none of in my blood results im never in sunlight due to being housebound at 42 for 3 yrs. I am short of breath last 3 wks and feeel i may have another P,Emblism will this supplement rid me of blood clots or prevent them ?
      thanks Donna D
    • Hello Donna - 

      I cannot safely recommend anything that has to do with D dimer or clotting times. These are things your physician must monitor and tightly control for your safety.

      Controlling your levels of inflammation and homocysteine are definitely supportive of reducing risk of blood clots. HomocysteX does support healthy levels of homocysteine but I have no way to tell you if it will also enable you to come of any blood thinners.

      Personally, I do recommend staying on some type of blood thinner and anti-clotting drug or supplement along with anti-inflammatory and homocysteine support.

      In health,Dr Ben 

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  • Multiple mutations at 6/30/12 11:42 AM
    • I have a family with different mutations: a 10 yr old with two copies of C677T (has bilateral Hydronephrosis, Aspergers, chromosome 16.13 microdeletion, mitochondrial disorder, GERD, Cyclical vomiting syndrome), a 6 yr old with one copy of each C677T and A1298C (mitochondrial disorder - mild) and a 2 year old with one copy of A1298C (GERD, speech delay, possible aspergers)... (I have yet to be tested (no insurance working on getting up the money now just to confirm but starting treatment) - the question being: what would the dosing be with this product? is it a set dose or by weight or age?

      We have considered Methyl B-12 shots but we would like to try something less invasive first. We have started to incorporate foods higher in B vitamins and we are switching over to more whole and raw foods as possible, we do not live close to a farmers market and we are trying to start a garden.
    • Hello - 

      I recommend starting slowly and more easily.

      The Sublingual Active B12 with Metafolin is a great nutrient to start with as it combines vitamin B12 and methylfolate in a tablet that goes under the tongue. 

      Start with 1/4 tablet first thing upon rising and watch their behavior for a few days. If improving or no change, then increase to 1/2 tablet and again watch. Keep doing this until you find the amount that works best - always increasing by 1/4 tablet.

      If you find anxiety, irritability, headaches, or other symptoms appear which were not there prior to giving this supplement, then reduce the amount given or stop it.

      Please work with your doctor on this.

      Should you need a consult for this complicated scenario(s), please do know that I am available to help you. You may set one up by calling 800-547-9812

      In health,

      Dr Ben 

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  • b6 intolerant(pyridoxine hcl) at 8/18/12 9:53 PM
    • Hello,
      I tested positive for heterozygous MTHFR gene mutations. I wanted to order either the Homocystex or the Homocystex+. I have tried taking B6 two separate times and each time by the 3rd day I experienced, headache, nausea and dizziness and by the 4th day I was barely able to get out of bed. The B6 I took was the pyridoxine HCl form. I feel certain I would tolerate the Sublingual Active B12 with 5MTHF, I tolerate sublingual meds so much better, but all I have read tells me that B6 would be very helpful for my condition so I wondered if you think there would be a chance I might tolerate the form of B6 in the Homocystex supplements. The reason I was tested for MTHFR was a moderatley elevated homocyseine level(14.9). I also have macrocythemia and many, many allergies & food intolerances & ADD but compared to the problems other people have I am relatively unscathed by the MTHFR.
      Thank you .
      Claire
    • Claire - 

      Given your high homocysteine, I recommend the HomocysteX Plus along with the Sublingual Active B12 with Metafolin. Use the Sublingual Active B12 with Metafolin first for a week or so - then switch to HomocysteX Plus.

      The form of B6 in HomocysteX Plus, P-5-P, is typically well-tolerated.

      HomocysteX Plus does provide greater nutrient power to help support healthy homocysteine levels.

      I also recommend ProBiota Sensitive - take 1 capsule after dinner. This may help support your food intolerances by improving your T regulatory cell balance.

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  • headaches at 11/27/12 5:13 PM
    • I know I need b6, but when I try to take the active form P5P even in very small amounts, I get a bad headache. I am heterozygous for C677T MTHFR. The other active forms of b vitamens don't seem to bother me. What is causing this as I know b6 is needed to move methylation forward.
      I would like to order homocystex. I understand the headache thing happens in some people, but can't find an explanation why.
      Because I ordered my MTHFR test from seeking health, that is how I found out I had it. Thanks so much. I am prone to migraines and am starting GAPS diet next week. Have been diagnosed with with SIBO. Don't know if that would have anything to do with it or not. LOVE YOUR SERVICE.
    • Hi there,

      Thank you for your question!  Are you taking the P5P as a separate supplement or is it in combination with methlyfolate?  Typically, the side effect of a headache signifies being overmethylated.  You are simply overdriving your neurotransmitter production and increasing methylation past the healthy point.  You may want to read and understand the side effects from methylfolate so you understand if you are taking too much or not:  http://mthfr.net/methylfolate-side-effects/2012/03/01/

      For people who are already over methylated, HomocysteX is not for them.  A good way to see if you are over methylated is to check your histamine levels.  Low histamine = overmethylated.  If methylation is not a concern, Homocystex is a great product.  In regard to dosage, Dr. Ben recommends starting out with very small dosage and slowly---1 capsule of HomocysteX for a few days, see how you feel and then increase from there.  It is not recommended to take HomocysteX within 5 hours of going to bed as it may keep you awake. Eventually, 3 capsules is a pretty standard dosage of HomocysteX, but remember….increase slowly!  Example regimens for 3 capsules are:  2 capsules in the AM and 1 capsule at lunch or around 2 PM or so.  Or, 1 capsule in the AM, one at lunch and another at least 5 hours before bedtime.  This way the blood levels of these critical nutrients stay where they should be and more of the nutrients are absorbed.

      Remember, start simply and expand on your regimen as long as you feel good or are noticing an improvement. If you take too many things at once or too high a dosage and don’t feel so hot, you may not know what is causing it.  Also, if taking a lot of things at once, a person may feel great initially for a few weeks, but then may get not so hot feelings down the road. This requires alteration in dosages and what is being taken.  In short, introduce one new supplement at a time and start with very low dosages.

      One common treatment for SIBO are probiotics.  There are numerous explanations for how probiotic bacteria might benefit individuals with SIBO.  However, the beneficial action has not been identified clearly.  It may be that the probiotic bacteria inhibit other bacteria in the intestine that may be causing symptoms, or it may be that the probiotic bacteria act on the host's intestinal immune system to suppress inflammation.  I recommend the Probiota 12 by Seeking Health.  It’s a wonderful probiotic!  http://healthygoods.com/pro-biota-12-powder-maximum-support-200-billion-cfus-twelve-species-60-grams-seeking-health.html

      I recommend you take ¼ teaspoon of ProBiota 12 nightly about 5-10 minutes after dinner. If you tolerate ¼ teaspoon, with time you may try increasing to ½ teaspoon. You may likely notice improved digestion, less gas and bloating, improved immune function, improved skin health and less fatigue.

      I recommend the use of Vitamin D360 which is a liquid vitamin D3. It contains 2,000 IU of vitamin D3 per DROP.  Start with 2 DROPS per day and test your vitamin D3 levels every three to five months or as recommended by your doctor. Vitamin D360 is found here: http://healthygoods.com/seeking-health-vitamin-d360-2-000-iu-per-drop.html 

      I hope this gets you off on the right track.

      In health and happiness,

      Kelly Harrington, MS, RD

      Nutritionist for Healthy Goods

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