Coenzyme Q10: inhibits the oxidation of LDL cholesterol, and protects mitochondrial and cellular membranes. Due to these cellular membrane and structural benefits, CoQ10 may be beneficial for a wide range of health conditions. CoQ10 has shown positive protective benefits for heart and neurological disease. Oxidized LDL cholesterol plays an important part in the pathogenesis of atherosclerosis. By protecting LDL from oxidative damage CoQ10 reduces the risk of atherosclerotic plaque formation. CoQ10 acts as a cofactor in the mitochondrial electron transport chain, where it accepts electrons from complex I and II, an activity directly involved in the production of cellular energy via ATP production.
CoQ10 has been an approved drug in Japan for use in congestive heart failure since 1974.
HMG-CoA reductase inhibiting cholesterol reducing medications can deplete CoQ10 levels, resulting in less cellular energy production and less antioxidant protection to all cellular tissues (cell membranes and cellular structures).
CoQ10 levels decrease with aging, due to reduced biosynthesis by the body. Supplemental CoQ10 may be beneficial. CoQ10 is fat soluble and therefore best taken with meals. The addition of an emulsifying agent, such as lecithin, can aid in the absorption of CoQ10.
CoQ10 reduced the symptoms of fatigue, chest pain, dyspnea (shortness of breath) and palpitations in patients with congestive heart failure. In some patients normal heart size and function were restored.
CoQ10 has shown positive efficacy in reducing gingival inflammation and periodontal pocket depth.
CoQ10 may help ameliorate the cardiotoxicity of doxorubicin.
Ongoing research is looking at the possibility of positive benefit of CoQ10 for immunological disorders, muscle wasting diseases, cancers, age related elevated blood sugar disorders, elevated blood pressure and chronic fatigue associated conditions. Currently these claims are inconclusive. More rigorous studies are needed.
Lecithin: is an emulsifying agent used to enhance the absorption of fat-soluble products. Lecithin may enhance the absorption of Coenzyme Q10.
Altar D, Mortensen SA, Flachs H, Herzog WR. Coenzyme Q10 protects ischemic myocardium in an open-chart swine model. Clin Investig. 71(Suppl):S103-S111, 1993.
Baggio E, Gandini R, Plancher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med. 15(Suppl):287-294, 1994.
Bergossi AM, Grossi G, Fioletta PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquone reduction induced by HMG-CoA reductase inhibitors. Mo Aspects Med. 15(Suppl):187-193, 1994.
Bliznakov EM, Wilkins DJ. Biochemical and clinical consequences of inhibiting coenzyme Q10 biosynthesis by lipidlowering HMG-CoA reductase inhibitors (statins). Advanc Therap. 15:218-228, 1998.
Hanioka T, Tanaka M, Oijima M, et al. Effect of topical application of coenzyme Q10 on adult periodontitis. Molec Aspects Med. 15 (Suppl):S241-S248, 1994.
Hofman-Bang C, Rehnqvist N, Swedberg K, et al. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 study group. J Card Fail. 1:101-107, 1995.
Lass A, Sohal RS. Effect of coenzyme Q10 and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals. FASEB J. 14:87-94, 2000.
Matthews RT, Yang L, Browne S, et al. Coenzyme Q10 administration increases mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA. 95:8892-8897, 1998.
Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects low-density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci USA. 88:1646-50, 1991.
PDR for Nutritional Supplements, 1st Ed. Medical Economics/Thompson Healthcare. 2001.
Werbach MR. Nutritional Influences on Illness: A Sourcebook of Clinical Research, 2nd Ed. Third Line Press, Tarzana, Calif. 1993.
Precautions: Coenzyme Q10 may decrease the effectiveness of warfarin (1 report).
Because no long-term safety studies have been done to confirm safety, pregnant and nursing mothers should avoid CoQ10 products. Due to possible improved glycemic control (Japanese clinical reports) in type ll diabetics, blood sugar levels should be monitored regularly and medication doses adjusted as indicated.
Adverse Reactions: Mild gastrointestinal symptoms such as nausea, diarrhea and epigastric distress have been reported, particularly with doses higher than 200 mg per day.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Cost Per Serving: $0.77
Additional notes: Keep tightly capped and store in a cool, dry place.
Brand: BioGenesis Nutraceuticals
Delivery type: Vegetarian Capsule
Contraindications: Consult your physician before use
Made In: USA
Serving size: 1 capsule
Servings per container: 60
|Coenzyme Q10||150 mg||-|
lecithin, coenzyme Q10
Cellulose, magnesium stearate, stearic acid
As a dietary supplement, take , 1-2 times per day or as directed by a healthcare professional.
Keep out of reach of children.
This product has been good so far doesn't upset my stomach like some CoQ10 products have. I don't seem to be as fatigued in the evenings since taking this product.
Order # 113705 (Posted on 10/17/12)
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