Seeking Health Liver Nutrients provides a balanced combination of nutrients that enhance and protect hepatic function by supporting liver detoxification processes and enzymatic pathways, and providing antioxidant protection. 60 veg caps
The liver is the body’s central detoxification organ, responsible for deactivating environmental toxins as well as those generated endogenously. If liver detoxification is compromised, either by poor nutritional status, excessive toxin exposure, or illness, toxins may accumulate with considerable negative health consequences.
The liver is equipped with several detoxification pathways, including excretion of toxins via bile, filtration of toxins from blood, and a two-phase enzymatic neutralization process, known as Phase I and Phase II. The majority of toxins (including xenobiotics, steroid hormones, and metabolic by-products) entering Phase I are converted by a family of enzymes into intermediates that are often more toxic than their precursor molecules. The intermediate metabolites are then neutralized during Phase II conjugation reactions via glutathione and amino acid conjugation, sulfation, methylation, acetylation, and glucuronidation. These Phase II reactions create water-soluble intermediates that are then excreted in urine and bile.
Free radicals are generated as a result of Phase I reactions. Thus, it is critical to support a proper balance of Phase I and Phase II activities to protect against oxidative damage to cell and cellular processes. There are numerous hepatoprotective nutrients that support Phase I and Phase II activities and protect against excessive free radical generation. Phase I and II reactions are critically dependent upon the availability of numerous nutrients.
Liver Nutrients provides several of these key nutrients as well as milk thistle extract which has unique hepatoprotective and regenerative properties. With the combination of 7 key ingredients, Liver Nutrients supports liver detoxification while providing antioxidant protection.
1. Milk Thistle (Silybum marianum)
Milk thistle extract is rich in the flavonolignins silybin, silydianin, and silychristin, collectively referred to as silymarin. Unique to milk thistle, silymarin is well documented in scientific literature as a powerful hepatoprotective flavonoid complex. Silymarin both enhances and protects healthy liver function through three principal mechanisms. Acting at the cell membrane, silymarin protects hepatic cells by blocking the transportation of hepatotoxins into the liver. Silymarin also acts as an antioxidant, protecting against lipid peroxidation. Silymarin further contributes to the liver’s antioxidant defenses by enhancing glutathione levels, a leading hepatic antioxidant. In addition to its protective functions, silymarin has regenerative properties in the liver. By stimulating protein synthesis, silymarin promotes the regeneration of damaged cells.
N-Acetyl-L-Cysteine (NAC) offers numerous hepatoprotective benefits that are primarily the result of its ability to increase endogenous glutathione levels and reduce oxidative stress. When metabolized, NAC generates L-cysteine, which is a precursor of glutathione. Glutathione deactivates many pro-oxidants, including hydroxyl radicals and superoxide radicals, and is required for the synthesis of glutathione peroxidase, another important liver antioxidant. NAC has been shown to increase endogenous synthesis of glutathione when demand for this potent antioxidant is high. NAC is itself a powerful antioxidant, capable of neutralizing hydrogen peroxide, hypochlorous acid, and hydroxyl radicals. Experimental studies indicate that NAC may protect the integrity of mitochondrial superoxide dismutase and glutathione peroxidase, two crucial hepatic antioxidants.
3. Alpha-Lipoic Acid
Alpha-lipoic acid is a powerful antioxidant that is both water and fat soluble, and thereby able to offer an unusually wide range of antioxidant protection. Alpha-lipoic acid not only protects the liver by deactivating free radicals, but it also helps build up the body’s antioxidant defenses by recycling other antioxidants, including glutathione and vitamins C and E. Alpha-lipoic acid has been shown beneficial in reducing toxicity caused by exposure to heavy metals, such as mercuryand cadmium, and other environmental toxins.
L-methionine is a precursor of L-cysteine, which in turn is an important precursor of glutathione. L-methionine has been shown to increase endogenous glutathione levels as well as prevent its depletion. As a result of bolstering glutathione levels, L-methionine indirectly supports the Phase II glutathione detoxification pathway as well as hepatic antioxidant defenses. Methionine alsosupports the Phase II methylation detoxification pathway by aiding in S-adenosylmethionine (SAM) synthesis, a key methyl donor in this detoxification pathway. Methionine is reported to support the excretion of toxins in bile. Finally, methionine is also an important precursor of taurine.
As a pivotal precursor of glutathione, L-cysteine is required to maintain sufficient stores of this primary hepatic antioxidant. Like L-methionine, L-cysteine has been shown to increase endogenous glutathione levels as well as prevent its depletion. By protecting glutathione levels, L-cysteine helps support the Phase II glutathione conjugation detoxification pathway and aids in controlling hepatic oxidative stress by bolstering glutathione stores. L-cysteine is also an important precursor for the endogenous synthesis of taurine.
Taurine is involved in a variety of detoxification processes, including bile acid conjugation, reduction of oxidative stress, and select Phase II detoxification pathways. In order to clear toxins, cholesterol, and excess fat-soluble vitamins from the body, bile acids form bile salt conjugates by binding with either taurine or glycine. As an antioxidant, taurine helps reduce oxidative stress by neutralizing hypochlorous acid. Finally, taurine is involved in the Phase II amino acid conjugation detoxification pathway in which specific amino acids bind to and deactivate toxins. Activity of another Phase II detoxification pathway, sulfation, may also be enhanced by taurine. Taurine can be synthesized endogenously in the liver using L-cysteine and L-methionine.
7. Trimethylglycine (betaine)
Trimethylglycine has been shown to help protect the liver against damage following carbon tetrachloride exposure in animal studies. Betaine has also been shown in animal studies to raise hepatic levels of S-adenosylmethionine (SAM) of both control animals as well as those fed ethanol. Studies in both animals and humans have shown SAM to be protective against the development of fatty liver that can occur with ethanol ingestion.
What you need to know
Maintenance and protection of liver function is known to be optimized by adequate intake of many additional nutritional factors, including the antioxidant vitamins C and E, beta-carotene, B vitamins, and selenium. It is thus recommended that Liver Nutrients be taken in conjunction with Optimal Multivitamin by Seeking Health for comprehensive nutritional support of liver health.
Suggested Use: 1 capsule twice daily or as directed by physician.
Drug Interactions:Potential adverse reactions may occur with concurrent use of NAC and metoclopramide and NAC and nitroglycerine.
Contraindications This product is not recommended for use during pregnancy and lactation.
60 veg caps
Dr. Ben Lynch, founder and Chief Medical Officer of Seeking Health, is a naturopathic physician. While majoring in Cell and Molecular biology at the University of Washington, Dr. Ben took a trip through the South Pacific and Southeast Asia that changed his outlook on traditional medicine, and his life.
During this trip, Dr. Ben hiked through the forests, mountains and coasts of Tasmania, worked a cattle ranch in the Outback of Australia, and volunteered with Mother Theresa in Calcutta. He lived in Fiji with a family having no electricity or plumbing, experienced the Himalayan Mountains of Northern India, worked a fruit orchard in New Zealand, and returned to America with an impression of a different form of medicine than he had ever experienced with his mainstream medical education.
This profound experience led Dr. Ben to Bastyr University, and he studied the Mind-Body Connection, Environmental Medicine, Functional Medicine, and Epigenetics.
Dr. Ben saw the huge need for people to obtain foundational nutrients, and Seeking Health was born. Without foundational nutrients, biochemical dysfunction occurs and causes symptoms. Doctor after doctor and person after person do not understand the absolute requirement for our bodies to have the tools to maintain function.
“If one supports their bodily systems, especially their digestion and mental health, with pure, highly absorbable, well-formulated nutrients, the ability to remain healthy and vital significantly increases. We want your foundation rock solid and we provide the tools to do so.”
-Dr. Ben Lynch, founder of Seeking Health
Seeking Health believes that the root cause for many health conditions and supplements stem from ineffective digestion, environmental exposures, poor diet, and lack of a healthy social outlet and inlet.
Seeking Health is here to see you get better, and stay better. Their true passion is prevention.
Seeking Health is based in Bellingham, Washington and operated and managed by a team dedicated to bringing you better health through the best quality supplements, prebiotics, probiotics, and multivitamins.
Seeking Health brings you effective formulas produced without preservatives, colors, titanium dioxide, coloring, or gluten.
Cost Per Serving: $0.33
Brand: Seeking Health
Delivery type: Vegetarian Capsule
Made In: Canada
Serving size: 1 capsule
Servings per container: 60
|Milk Thistle (Silybum marianum) fruit, dried extract, min. 80% silymarin||200 mg||*|
|N-Acetyl-L-Cysteine USP||150 mg||*|
|Alpha-Lipoic Acid||50 mg||*|
|Taurine USP||50 mg||*|
|Trimethylglycine (betaine)||150 mg||*|
Vegetarian capsule (hydroxypropyl methylcellulose, water), silicon dioxide, L-leucine, natural citrus flavor, and natural vanilla flavor.
Take 1 capsule of Liver Nutrients twice daily with food or as recommended by your health professional.
Do not use if full-bottle shrink wrap is broken or missing. Store in a cool, dry place (59-85 degrees) away from direct sunlight. Keep out of reach of children.
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