Mushroom Science Coriolus PSP is one of the most effective and best selling immune support supplements in the world. With health benefits verified by hundreds of studies and multiple human clinical trials, it is also one of the most thoroughly researched medicinal mushroom supplements used for immune support. 90 count

  • Mushroom Science Coriolus PSP, 90 count

Mushroom Science Coriolus PSP, 90 count

Mushroom Science Coriolus PSP is one of the most effective and best selling immune support supplements in the world. With health benefits verified by hundreds of studies and multiple human clinical trials, it is also one of the most thoroughly researched medicinal mushroom supplements used for immune support. 90 count

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Mushroom Science Coriolus PSP (Turkey Tail)

Also known as the turkey tail mushroom or Trametes versicolor, Coriolus versicolor enjoys a long history of use and recognition in Traditional Chinese Medicine with appearances in traditional herbal texts dating as far back as the early 15th century. Coriolus PSP was developed by Dr. Yang of the Shanghai Teachers College in the 1980's. Contrary to some claims, PSP and PSK can be produced from any strain of Coriolus versicolor and can be extracted from the mushroom fruit bodies or the mycelium, as long as the mycelium is grown through submerged culture in a liquid medium.

Coriolus versicolor in History

Decoctions of Coriolus versicolor have been used for centuries in Traditional Chinese Medicine (TCM), with references in the Chinese Compendium of Materia Medica dating as far back as the 15th century.

Coriolus PSP vs. PSK

The Coriolus extract called PSP (Polysaccharide-Peptide) was first developed in China during the late 1980s, about 15 years after the first studies on the Japanese extract PSK (a.k.a. Krestin or Coriolus Super Strength) were published.

The main difference between the two extracts is that PSP contains both peptides and proteins in the non-glucan portion of the molecule, but contains more peptides than proteins.  PSK also contains both peptides and proteins in the non-glucan portion of the molecule, but contains more proteins than peptides. PSP therefore is classified as a polysaccharide-peptide, PSK is classified as a protein-bound polysaccharide.

There are also minor differences in the non-active single sugars, however, in the glucan portion of both PSP and PSK, the part considered to be biologically active for immune support purposes, is identical under NMR analysis (Nuclear Magnetic Resonance Imaging).

This difference in the peptide-protein ratio between PSP and PSK is due to the fact that precipitation with alcohol is used as a secondary step in the extraction process for PSP.  

The Science of Coriolus versicolor

Precipitation with alcohol was first developed by Chinese researchers and represents a significant and important innovation in the hot water extraction process for medicinal mushrooms. The “old” method of separating the bio-active heavy molecular weight polysaccharides from the lighter weight non-active single sugars was to use evaporation alone (after the hot water extraction step).

The lighter molecular weight single sugars are the first compounds to be separated from the hot water extract mixture as they leave with the evaporated steam, prior to the spray drying step that converts the concentrate to a powder. The heavier molecular weight polysaccharides that contain the beta glucans, because they are in fact heavier, remain in solution after a significant percentage of the single sugars are evaporated out.  However, this is a lengthy and energy intensive process.

What the Chinese did was to use the natural properties of the active compounds, the polysaccharides that contain the beta glucans, to speed up the process of concentrating them prior to spray drying. The bio-active polysaccharides in medicinal mushrooms are not alcohol soluble.  So after the initial hot water extraction step, the Chinese researchers began adding alcohol to the liquid extract solution.  At a certain concentration of added alcohol the heavy molecular weight polysaccharides that contain the beta glucans will separate, while still in solution, from the single sugars.  

After the heavy molecular weight polysaccharides separate from the other non-active single sugars, they are siphoned off into the evaporation tank for further concentration.

As opposed to using evaporation alone, using precipitation with alcohol first is a much faster and far more efficient way to concentrate and separate the active compounds from the non-active single sugars. Although the beta glucan portion of the molecule is not affected by precipitation with alcohol, this process does release some of the protein links in the long-chain polysaccharide molecule.  This reduces the mass, resulting in those portions of the molecule to be re-classified as peptide links instead of protein links.

Coriolus Traditional Use and Preparation

According to the references from TCM, Coriolus is sweet in taste and slightly warm in nature, acting through the spleen and heart meridians. It dispels damp and reduces phlegm. In TCM, all the references have Coriolus prepared as a hot-water-extract.  There are no references from TCM citing the use of ground up Coriolus mushrooms or tinctures of Coriolus.

Hot Water Extracted: Dr. Mark Stengler N.D., in his recent book, The Health Benefits of Medicinal Mushrooms, made the observation that all of the independent scientific studies on medicinal mushrooms are based on the use of hot water extracts. All of the references from Traditional Chinese Medicine also recommend hot water extraction when preparing medicinal mushrooms. There are two main factors involved:

Bioavailability - The immune-supporting polysaccharides common to all medicinal mushrooms and mushroom mycelium are found inside of the cell walls. However, the cell walls are made from an indigestible fiber called "chitin", the same material a lobster shell is made of. Hot water extraction is the only clinically validated method for breaking these polysaccharides out of the indigestible cell walls. Even soft mushrooms like shiitake are prepared as a hot water extract or a tea when used medicinally.

Concentration - The immune supporting polysaccharides found in the cell walls of mushrooms and mushroom mycelium comprise only 0.5-2% of the total mass by dry weight (depending on the mushroom), not enough to have effect even if they were bioavailable. Most hot water mushroom/mycelium extracts are at least a 20:1 concentration. Hot water extraction dissolves the indigestible fiber (chitin), allowing the fiber to be removed from the extract when the water is removed. This process concentrates the polysaccharides to the effective levels identified in the published research.

Hot water extracts (dehydrated) are 50-80 times more potent than tinctures (cold water extracts) or mycelium biomass.

Active Constituents

28% polysaccharides

Each bottle contains 90 vegetarian capsules, 400 mg per capsule.

Suggested Use: 1-3 capsules twice daily, AM and PM, or more as recommended by your health care professional. Take on an empty stomach.

About Mushroom Science

The staff at Mushroom Science are dedicated to providing their customers with the highest quality medicinal mushroom products possible. A commitment to good health allows no less.

  • • MushroomScience grows their own certified all natural mushrooms, on chemical-free wood, the way nature intended.
  • • Every extract is carefully prepared, capturing the complete essence of what made these medicinal mushrooms valuable in the ancient herbal traditions of Japan and China.

While medicinal mushrooms have been used for thousands of years in Traditional East Asian Medicine, rigorous scientific testing on the use of these mushrooms has been conducted only in the past thirty years. However, those thirty years of research have produced a wealth of information. They find that on all of the important points, science supports the preparation and use of medicinal all-natural mushrooms as described in the texts on Traditional Chinese Medicine.

This knowledge, a point of convergence between the clinical traditions of East and West, is the foundation of their approach to quality, and guides every step of their manufacturing and quality control process. It is your guarantee that you are purchasing a quality medicinal mushroom product specifically formulated to deliver the active constituents unique to each mushroom.

The Mushrooms of Immortality: Reishi Mushrooms
Mushroom Science Coriolus PSP, 90 count
Manufacturer: Discontinued

Botanical Name: Coriolus versicolor

Item number: MUS010

GTIN: 669214868181

Warnings: Keep out of reach of children. Do not use if allergic to mushrooms, pregnant or breast feeding. Do not use if safety seal around top of bottle is missing or broken. Store at room temperature, with lid closed.

Form: Vegetarian Capsule

Package Size: 90

Serving Size: 1 Capsule

Serving Per Package: 90

Refrigeration Required: No

Ingredients: Vegetarian Capsules (cellulose), Ganoderma lucidum mycelium, myceliated rice.


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