4.714 reviews

Seeking Health HomocysteX Plus supplies bioactive forms of four essential B-Vitamins together with betaine (also known as trimethlglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism.  This formula is exceptional for those with defective MTHFR genes.  60 veg caps. 

4.714 reviews
  • Seeking health homocystex plus 60ct

Seeking Health HomocysteX Plus, 60 ct

Seeking Health HomocysteX Plus supplies bioactive forms of four essential B-Vitamins together with betaine (also known as trimethlglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism.  This formula is exceptional for those with defective MTHFR genes.  60 veg caps. 

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Seeking Health Homocystex Plus, 60 veg caps

Homocystex Plus takes the four essential B complex vitamins from Homocystex and adds vitamin B2 and betaine (as trimethylglycine as TMG). 

The body’s methylation process is vital for formation of essential cell components such as proteins, the nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes.  Methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite.

Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body. To nutritionally support optimal methylation capacity, HomocysteX Plus supplies folate, vitamins B12, B6, B2, and betaine in amounts and forms that are efficiently utilized and well-tolerated by the body.

Helps maintain normal homocysteine metabolism

Optimizing homocysteine metabolism can play an important role in maintaining healthy cardiovascular and cognitive functions. Homocysteine can either be converted to the amino acid cysteine through a series of vitamin B6-dependent reactions or converted to the essential amino acid methionine through a methylation reaction involving folate and vitamin B12.

HomocysteX Plus supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism. This formula is exceptional for those with defective MTHFR genes. Taking just 5-MTHF is not sufficient for those with MTHFR mutations, which is why Homocystex Plus provides these other ingredients to help lower homocysteine and support the methylation cycle.

Supports methylation processes

Most methylation reactions involve the molecule S-adenosylmethionine (SAM) as a methyl group donor. Thus, supporting the formation of SAM can be a viable approach to supporting methylation processes.

Folate and vitamin B12 support methylation capacity, as they are essential players in the pathway that produces SAM. Vitamin B2 and betaine also play various different roles to help ensure adequate SAM production, whereas vitamin B6 contributes to methylation processes by facilitating the formation of methyl groups. For optimal nutrient absorption and utilization, this product provides biologically active forms of folate (as Metafolin® ** L-5-methyltetrahydrofolate) and vitamin B12 (as methylcobalamin). These forms are already fully "active” and readily usable, as they do not require further metabolism in the body. Active forms of vitamin B2 (as riboflavin 5’-phosphate) and vitamin B6 (as pyridoxal 5’-phosphate) are also provided for highest absorption and bio-availability.

Some individuals are more susceptible to homocysteine accumulation as they are unable to fully convert common forms of folate (such as oxidized folic acid) and B12 (such as cyanocobalamin) into their active forms. In contrast, providing folate and vitamin B12 in their active, methylated forms provides a reliable approach to supporting homocysteine metabolism. Betaine also assists homocysteine regulation through an alternative pathway in which it supplies important methyl groups that allow homocysteine to be safely converted to methionine.

Suggested Use: 1 capsule daily with food. 60 veg caps


About Seeking Health, the company

Dr. Ben Lynch, founder and Chief Medical Officer of Seeking Health, is a naturopathic physician. While majoring in Cell and Molecular biology at the University of Washington, Dr. Ben took a trip through the South Pacific and Southeast Asia that changed his outlook on traditional medicine, and his life.

During this trip, Dr. Ben hiked through the forests, mountains and coasts of Tasmania, worked a cattle ranch in the Outback of Australia, and volunteered with Mother Theresa in Calcutta. He lived in Fiji with a family having no electricity or plumbing, experienced the Himalayan Mountains of Northern India, worked a fruit orchard in New Zealand, and returned to America with an impression of a different form of medicine than he had ever experienced with his mainstream medical education.

This profound experience led Dr. Ben to Bastyr University, and he studied the Mind-Body Connection, Environmental Medicine, Functional Medicine, and Epigenetics.

Dr. Ben saw the huge need for people to obtain foundational nutrients, and Seeking Health was born. Without foundational nutrients, biochemical dysfunction occurs and causes symptoms. Doctor after doctor and person after person do not understand the absolute requirement for our bodies to have the tools to maintain function.

  • • Without water, we die.
  • • Without food, we die.
  • • Without probiotics, we get digestive disorders.
  • • Without multivitamins, we become depressed, fatigued and sick.

“If one supports their bodily systems, especially their digestion and mental health, with pure, highly absorbable, well-formulated nutrients, the ability to remain healthy and vital significantly increases. We want your foundation rock solid and we provide the tools to do so.”

-Dr. Ben Lynch, founder of Seeking Health

Seeking Health believes that the root cause for many health conditions and supplements stem from ineffective digestion, environmental exposures, poor diet, and lack of a healthy social outlet and inlet.

  • • Once digestion is restored and optimized with the best probiotics, digestive enzymes, stomach acid and intestinal repair nutrients, one is able to absorb nutrients from foods and high quality multivitamins.
  • • Once environmental exposures are reduced, one is able to reduce toxic burden which then frees up nutrients to work in promoting health and preventing disease.
  • • Once diet is optimized, nutrients flood in, energy increases, blood sugar stabilizes and the immune system balances.
  • • Creating a social outlet and inlet allows the parasympathetic nervous system to regain control over the reactive sympathetic nervous system, allowing countless nutrients to be used proactively and in a protective manner instead of being wasted on producing stress hormones.

Seeking Health is here to see you get better, and stay better. Their true passion is prevention.

Seeking Health is based in Bellingham, Washington and operated and managed by a team dedicated to bringing you better health through the best quality supplements, prebiotics, probiotics, and multivitamins.

Seeking Health brings you effective formulas produced without preservatives, colors, titanium dioxide, coloring, or gluten.

Seeking Health HomocysteX Plus, 60 ct
Product Certifications:
Manufacturer: Seeking Health

Item number: SKH028

GTIN: 700580723534

Warnings: Keep Out Of Reach Of Children

Serving Size: 1

Serving Per Package: 60 Vegetarian capsules

Suggested Use: 1 capsule daily with food or as directed by your physician. May be combined with L-5-MTHF 1000 by Seeking Health should additional methylated folate be required.

Refrigeration Required: No

Does Not Contain:
Tree Nuts
Supplement Facts:
Vitamin B2 (as riboflavin 5'-phosphate) 30 mg1765%
Vitamin B6 (from 25 mg pyridoxal 5'-phosphate) 15 mg750%
Folate (as Metafolin L-5-methyltetrahydrofolate) 800 mcg200%
Vitamin B12 (as methylcobalamin 1000 mcg16,667%
Betaine (trimethylglycine as TMG) 600 mg-
 * = Daily Value Based on a standard 2,000 calorie daily intake
** = Daily Value Not Established

Other Ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), cellulose, L-leucine, and silicon dioxide.


Share your Experience With Others!

    "Homocystex plus"
  1. Review by Arneille L.
    Posted on 1/10/2018

    Effective. Orders received quickly.

  2. Seeking Health HomocysteX Plus, 60 ct 5
    "Great product, helped my husband"
  3. Review by Shelley W.
    Posted on 12/26/2017

    Great product, helped my husband get his blood pressure under control

  4. Seeking Health HomocysteX Plus, 60 ct 5
    "If you have MTHFR this"
  5. Review by Vickie S.
    Posted on 8/22/2016

    If you have MTHFR this product is a must have.

  6. Seeking Health HomocysteX Plus, 60 ct 5
    "I don't know if its"
  7. Review by Jeanna Z.
    Posted on 1/4/2016

    I don't know if its working. I do not feel any 'physical difference'

  8. Seeking Health HomocysteX Plus, 60 ct 5
    "Have noticeably helped with energy"
  9. Review by Kate W.
    Posted on 12/2/2015

    Have noticeably helped with energy levels and increased sense of resilience.

  10. Seeking Health HomocysteX Plus, 60 ct 5
    "So thankful for this product!"
  11. Review by April
    Posted on 11/8/2012

    I have had 5 miscarriages and one baby girl loss at 21 weeks due to several issues but one of them being MTHFR homozygous c677t. I tried what the docs told me to do and realized it wasn't working. So thankful through contacts God led me to Dr. Ben and these products. I started this one and Thorne Prenatal Vitamins right before I got pregnant this time and we are doing wonderful so far at almost 19 weeks along! I really believe this product is REALLY helping me and baby! Thanks!

  12. Seeking Health HomocysteX Plus, 60 ct 5
    "Great Product"
  13. Review by tobysmom
    Posted on 10/16/2012

    Our family has been on a variety of prescription Metafolate. I was a bit confused to see the fillers and artificial colors in these products. My understanding is that Metafolate can help people with the MTHFR gene detox. It made sense to me to avoid things that hindered detoxing. I so appreciate Homocystex! It contains what I need without artificial fillers or colors.

    Order # 164778

  14. Seeking Health HomocysteX Plus, 60 ct 5
    "Wonderful Product!"
  15. Review by Jeannie
    Posted on 10/16/2012

    My two children and I have MTHFR and have been using Metanx. I purchased HomeosysteX Plus and L-5-MTHF 1000 to replace Metanx. Very pleased with the results. Feel like it does a better job than Metanx.

  16. Seeking Health HomocysteX Plus, 60 ct 5
    "HomocysteX and depression"
  17. Review by Garland
    Posted on 10/16/2012

    My fiance is heterozygous 1298 and 677 for the MTHFR gene mutation. She saw I was suffering with mild depression and my anti depressants were not working. She suggested that I try HomocysteX by Seeking Health and it is working better than any pharmaceutical that I have ever used.

    My depression is gone and I am now getting tested for MTHFR.

    Order Number : 148418

  18. Seeking Health HomocysteX Plus, 60 ct 5
    "Great Product!"
  19. Review by Lynn
    Posted on 10/16/2012

    This is a very complete product. I have been taking only B-12 and Folic Acid in the methyl forms. I did not realize how important it is to have B-6 and the other ingredients in this product. It makes a world of difference in the way it makes me feel. Thanks for all the great information as well.

    Order # 155418

  20. Seeking Health HomocysteX Plus, 60 ct 5
    "Pregnant after 4 chemical pregnancies"
  21. Review by Lis
    Posted on 10/16/2012

    After having 4 chemical pregnancies I found out I'm homozygous C677t. I started taking this in addition to my prenatal and fish oil supplements and I'm now 5 weeks pregnant. I think the active folic acid may have made this possible. I'm now trying to find a prenatal with L-5-MTHF but will continue to take this following my pregnancy.

  22. Seeking Health HomocysteX Plus, 60 ct 5
  23. Review by Helen
    Posted on 10/16/2012

    Could definitely see IMMEDIATE changes in my energy level! I was hesitant taking it on an empty stomach first thing in the morning, but I've had no problems with nausea. HomocysteX, where have you been all my life?!

  24. Seeking Health HomocysteX Plus, 60 ct 5
    "Thank you Dr. Lynch"
  25. Review by SuzieQ
    Posted on 10/16/2012

    I took a bottle of HomocysteX to my doctor's appt. My doctor looked at the ingredients with interest. He was very impressed with the ingredient list of HomocysteX Plus. I so appreciate this supplement,
    there is nothing else like it.

    # 167676

  26. Seeking Health HomocysteX Plus, 60 ct 5
    "Not Good for People with Reynauds"
  27. Review by jusmeamom
    Posted on 10/16/2012

    I am homozygous for MTHFR so i thought this would be an excellent product for me. In addition to the MTHFR problem i also suffer from Reynaud's syndrome. I am very careful about cold exposure and have very few bouts normally. Once I started taking the Homocystex, I started having bouts in both my hands and feet several times a day. I RARELY get them in my feet. I stopped the Homocystex and immediately the bouts stopped, but once i tried taking the Homocystex again they returned. Unfortunately I wasted $27.95 to find out. I hope my experience can help someone else. I will be going back to high doses of Folinic acid (Leucovorin), which helped with my energy level and did not bring on Reynaud's issues. I wish this product had worked for me:(

    Order # 100018392

    Sorry to hear that HomocysteX did not work well for you. HomocysteX is a potent product - and when used by people having the right biochemistry - works amazingly well.

    Some people - especially those homozygous A1298C - do not seem to do well with HomocysteX. This is likely because they are already methylating fairly well but not getting enough BH4. Having worked with many with A1298C, I have found that HomocysteX does not work well for them. This is not a blanket statement as there are life circumstances, other mutations and environmental factor in play which cause a variation from person to person and this causes some things to work well for some and not for others.

    Raynauds tends to do well with increased niacin, magnesium, stress relievers, contrast hot/cold therapy, healing the gut, vitamin D3 to name a few.

    For people who are already over methylated, HomocysteX is not for them. A good way to see if you are over methylated is to check your histamine levels. Low histamine = overmethylated according to Dr Pfeiifer.

  28. Seeking Health HomocysteX Plus, 60 ct 1
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